Smart nanoprobe illuminates prostate cancer cells

Smart nanoprobe illuminates prostate cancer cells

Science Highlights

kolsen

Thu, 04/11/2024 – 09:35

NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a s…

Smart nanoprobe illuminates prostate cancer cells
Science Highlights
kolsen
NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a signal using an optical imaging technique known as Raman spectroscopy. The new probe, evaluated in mice, has the potential to determine tumor aggressiveness and could also enable sequential monitoring of tumors during therapy to quickly determine if a treatment strategy is working.

Development and validation of an ultrasound-based deep learning radiomics nomogram for predicting the malignant risk of ovarian tumours

The timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on u…

The timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on u...

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

Nature Biomedical Engineering, Published online: 08 April 2024; doi:10.1038/s41551-024-01197-4The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric an…

Nature Biomedical Engineering, Published online: 08 April 2024; doi:10.1038/s41551-024-01197-4

The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric and liposomal nanomedicines, as shown for specimens of mouse and human tumours.

Strategies to enhance the ability of nerve guidance conduits to promote directional nerve growth

Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading to loss of nerve function. To address this problem, various nerve guidance conduits …

Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading to loss of nerve function. To address this problem, various nerve guidance conduits ...

NIBIB-led program has helped innovators pursue commercialization for a decade

NIBIB-led program has helped innovators pursue commercialization for a decade

Science Highlights

clehmann

Fri, 04/05/2024 – 10:53

NIBIB is marking the 10-year anniversary of a commercialization program that helps inno…

NIBIB-led program has helped innovators pursue commercialization for a decade
Science Highlights
clehmann
NIBIB is marking the 10-year anniversary of a commercialization program that helps innovators bring their medical devices from the lab to the marketplace.

Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01203-9Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental …

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01203-9

Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi

Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01200-yAuthor Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01200-y

Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

A deep learning framework for identifying and segmenting three vessels in fetal heart ultrasound images

Congenital heart disease (CHD) is one of the most common birth defects in the world. It is the leading cause of infant mortality, necessitating an early diagnosis for timely intervention. Prenatal screening us…

Congenital heart disease (CHD) is one of the most common birth defects in the world. It is the leading cause of infant mortality, necessitating an early diagnosis for timely intervention. Prenatal screening us...

A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01190-xThe esterification of butyrate to serine makes for an odourless and tasteless oral prodrug that ameliorated disease severity and reduced infl…

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01190-x

The esterification of butyrate to serine makes for an odourless and tasteless oral prodrug that ameliorated disease severity and reduced inflammatory responses in mouse models of rheumatoid arthritis and multiple sclerosis.

Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01195-6Antigen-specific immunosuppression can be enhanced by genetically modifying mesenchymal stromal cells with chimaeric antigen receptors, as sh…

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01195-6

Antigen-specific immunosuppression can be enhanced by genetically modifying mesenchymal stromal cells with chimaeric antigen receptors, as shown for the treatment of graft-versus-host disease in mice.