Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells

Nature Biomedical Engineering, Published online: 19 April 2024; doi:10.1038/s41551-024-01194-7The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate i…

Nature Biomedical Engineering, Published online: 19 April 2024; doi:10.1038/s41551-024-01194-7

The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.

NIH Neuromod Prize Announces Phase 2 Winners

NIH Neuromod Prize Announces Phase 2 Winners

NIBIB in the News

cooperca2

Thu, 04/18/2024 – 11:34

NIH announced the Phase 2 winners of the Neuromod prize competition.

NIH Neuromod Prize Announces Phase 2 Winners

cooperca2
NIH announced the Phase 2 winners of the Neuromod prize competition.

Voxel-wise body composition analysis using image registration of a three-slice CT imaging protocol: methodology and proof-of-concept studies

Computed tomography (CT) is an imaging modality commonly used for studies of internal body structures and very useful for detailed studies of body composition. The aim of this study was to develop and evaluate…

Computed tomography (CT) is an imaging modality commonly used for studies of internal body structures and very useful for detailed studies of body composition. The aim of this study was to develop and evaluate...

Smart nanoprobe illuminates prostate cancer cells

Smart nanoprobe illuminates prostate cancer cells

Science Highlights

kolsen

Thu, 04/11/2024 – 09:35

NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a s…

Smart nanoprobe illuminates prostate cancer cells

kolsen
NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a signal using an optical imaging technique known as Raman spectroscopy. The new probe, evaluated in mice, has the potential to determine tumor aggressiveness and could also enable sequential monitoring of tumors during therapy to quickly determine if a treatment strategy is working.

Development and validation of an ultrasound-based deep learning radiomics nomogram for predicting the malignant risk of ovarian tumours

The timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on u…

The timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on u...

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

Nature Biomedical Engineering, Published online: 08 April 2024; doi:10.1038/s41551-024-01197-4The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric an…

Nature Biomedical Engineering, Published online: 08 April 2024; doi:10.1038/s41551-024-01197-4

The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric and liposomal nanomedicines, as shown for specimens of mouse and human tumours.

Strategies to enhance the ability of nerve guidance conduits to promote directional nerve growth

Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading to loss of nerve function. To address this problem, various nerve guidance conduits …

Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading to loss of nerve function. To address this problem, various nerve guidance conduits ...

NIBIB-led program has helped innovators pursue commercialization for a decade

NIBIB-led program has helped innovators pursue commercialization for a decade

Science Highlights

clehmann

Fri, 04/05/2024 – 10:53

NIBIB is marking the 10-year anniversary of a commercialization program that helps inno…

NIBIB-led program has helped innovators pursue commercialization for a decade

clehmann
NIBIB is marking the 10-year anniversary of a commercialization program that helps innovators bring their medical devices from the lab to the marketplace.

Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01203-9Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental …

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01203-9

Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi

Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01200-yAuthor Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01200-y

Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation