Researchers from Mass General Brigham and their collaborators present Tripath: new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions. In collaboration with the University of Washington, the research team imaged curated prostate cancer specimens, using two 3D high-resolution imaging techniques. Tripath performed better than pathologists and outperformed deep learning models that rely on 2D morphology and thin tissue slices. Source: Mass General Brigham
Nature Biomedical Engineering, Published online: 10 May 2024; doi:10.1038/s41551-024-01210-wBioluminescent sources can be detected with magnetic resonance imaging by leveraging the light-mediated activation of vascular cells expressing…
Bioluminescent sources can be detected with magnetic resonance imaging by leveraging the light-mediated activation of vascular cells expressing a photosensitive bacterial enzyme that causes alterations in local haemodynamic contrast.
Measuring heart rate or body temperature may sound easy, but retrieving the data from small animals with bulky traditional tech is difficult, especially during behavioral tests, which are critical for understanding brain disorders. Thanks to a recent study, the animal data is now in reach.
A new study involved high-resolution scans that enabled the researchers to visualize brain connections at submillimeter spatial resolution. Together, these pathways form a 'default ascending arousal network' that sustains wakefulness in the resting, conscious human brain. Source: Massachusetts General Hospital
Malignant primary brain tumors are the leading cause of cancer deaths among children and young adults with few therapeutic options. A preclinical study in Pharmaceutics shows that combining focused ultrasound with microbubbles opened the blood brain barrier to deliver immunotherapy into the brain of a large animal model.
Penn State researchers have discovered two proteins that differentiate stem cells into the components of blood vessels. The finding has implications for drug testing and other clinical applications. Source: Penn State
Nature Biomedical Engineering, Published online: 07 May 2024; doi:10.1038/s41551-024-01208-4Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher hu…
Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.
Nature Biomedical Engineering, Published online: 06 May 2024; doi:10.1038/s41551-024-01206-6Transthoracic ultrasound localization microscopy enables super-resolution imaging of myocardial microvasculature and haemodynamics in patients …
Transthoracic ultrasound localization microscopy enables super-resolution imaging of myocardial microvasculature and haemodynamics in patients with impaired myocardial function using data acquired within a breath hold.
Nature Biomedical Engineering, Published online: 06 May 2024; doi:10.1038/s41551-024-01209-3Durable and robust lymph-node expansion is associated with the efficacy of therapeutic vaccination, as shown in mice immunized via a biomateria…
Durable and robust lymph-node expansion is associated with the efficacy of therapeutic vaccination, as shown in mice immunized via a biomaterial-based vaccine.
Sleep-disordered breathing (SDB) affects a significant portion of the population. As such, there is a need for accessible and affordable assessment methods for diagnosis but also case-finding and long-term fol…
Sleep-disordered breathing (SDB) affects a significant portion of the population. As such, there is a need for accessible and affordable assessment methods for diagnosis but also case-finding and long-term fol...
