Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity

Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01189-4The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates…

Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01189-4

The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates avenues for enhancing the efficacy of T cell-targeted immune therapies.

Mineralized bacteria as an immunotherapy agent against various cancer types

Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01192-9By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multipl…

Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01192-9

By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects.

Wireless, light-powered pacemaker shines bright in animal study

Wireless, light-powered pacemaker shines bright in animal study

Science Highlights

jgriffin

Tue, 03/26/2024 – 14:53

While pacemakers have been instrumental in treating many patients with heart rhythm disorders, their …

Wireless, light-powered pacemaker shines bright in animal study

jgriffin
While pacemakers have been instrumental in treating many patients with heart rhythm disorders, their bulky design and dependence on wires can limit their usefulness and poses a risk of heart damage or infection. Researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.

Bioelectronic mesh capable of growing with cardiac tissues for comprehensive heart monitoring

Bioelectronic mesh capable of growing with cardiac tissues for comprehensive heart monitoring

NIBIB in the News

clehmann

Tue, 03/26/2024 – 14:16

A team of engineers led by the University of Massachusetts Amherst and i…

Bioelectronic mesh capable of growing with cardiac tissues for comprehensive heart monitoring

clehmann

A team of engineers led by the University of Massachusetts Amherst and including colleagues from the Massachusetts Institute of Technology (MIT) recently announced in the journal Nature Communications that they had successfully built a tissue-like bioelectronic mesh system. The mesh can grow along with the cardiac cells, allowing researchers to observe how the heart's mechanical and electrical functions change during the developmental process.

Source: University of Massachusetts Amherst

Methods, techniques, assays and protocols

Nature Biomedical Engineering, Published online: 25 March 2024; doi:10.1038/s41551-024-01199-2Applied biomedical research needs more of them to be more broadly useful, reproducible and robust.

Nature Biomedical Engineering, Published online: 25 March 2024; doi:10.1038/s41551-024-01199-2

Applied biomedical research needs more of them to be more broadly useful, reproducible and robust.

The future of at-home molecular testing

The future of at-home molecular testing

NIBIB in the News

raymond.macdougall

Fri, 03/22/2024 – 12:07

Many companies are now developing isothermal genetic tests that can diagnose a wide array of respiratory diseases, s…

The future of at-home molecular testing

raymond.macdougall

Many companies are now developing isothermal genetic tests that can diagnose a wide array of respiratory diseases, sexually transmitted infections and more. These products aim to provide precise and prompt diagnostic information, enabling people to quickly seek appropriate medical treatment. Source: Nature

Researchers report rare but persistent false positives on COVID-19 home antigen tests

Researchers report rare but persistent false positives on COVID-19 home antigen tests

NIBIB in the News

raymond.macdougall

Thu, 03/21/2024 – 11:21

UMass Chan Medical School researchers have documented a phenomenon that…

Researchers report rare but persistent false positives on COVID-19 home antigen tests

raymond.macdougall

UMass Chan Medical School researchers have documented a phenomenon that had confounded clinicians: Some people persistently test positive for SARS-CoV-2, the virus that causes COVID-19, on rapid home antigen tests despite obtaining concurrent negative PCR tests. Source: Medical Xpress

Oncolytic mineralized bacteria as potent locally administered immunotherapeutics

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01191-wIntratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activ…

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01191-w

Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.

PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01188-5Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tu…

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01188-5

Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells.

Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01193-8Cascaded diffusion models can be used to synthesize realistic whole-slide image tiles from latent representations of RNA-sequencing data from…

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01193-8

Cascaded diffusion models can be used to synthesize realistic whole-slide image tiles from latent representations of RNA-sequencing data from human tumours.