The diagnostic test for vasovagal syncope (VVS), the most common cause of syncope is head-up tilt test (HUTT) assessment. During the test, subjects experienced clinical symptoms such as nausea, sweating, pallo…
The diagnostic test for vasovagal syncope (VVS), the most common cause of syncope is head-up tilt test (HUTT) assessment. During the test, subjects experienced clinical symptoms such as nausea, sweating, pallo...
Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01189-4The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates…
The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates avenues for enhancing the efficacy of T cell-targeted immune therapies.
Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01192-9By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multipl…
By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects.
While pacemakers have been instrumental in treating many patients with heart rhythm disorders, their bulky design and dependence on wires can limit their usefulness and poses a risk of heart damage or infection. Researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.
A team of engineers led by the University of Massachusetts Amherst and including colleagues from the Massachusetts Institute of Technology (MIT) recently announced in the journal Nature Communications that they had successfully built a tissue-like bioelectronic mesh system. The mesh can grow along with the cardiac cells, allowing researchers to observe how the heart's mechanical and electrical functions change during the developmental process.
Nature Biomedical Engineering, Published online: 25 March 2024; doi:10.1038/s41551-024-01199-2Applied biomedical research needs more of them to be more broadly useful, reproducible and robust.
Many companies are now developing isothermal genetic tests that can diagnose a wide array of respiratory diseases, sexually transmitted infections and more. These products aim to provide precise and prompt diagnostic information, enabling people to quickly seek appropriate medical treatment. Source: Nature
UMass Chan Medical School researchers have documented a phenomenon that had confounded clinicians: Some people persistently test positive for SARS-CoV-2, the virus that causes COVID-19, on rapid home antigen tests despite obtaining concurrent negative PCR tests. Source: Medical Xpress
Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01191-wIntratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activ…
Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.
Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01188-5Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tu…
Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells.