Author: Nature Biomedical Engineering

Streamlining point-of-care assays

Nature Biomedical Engineering, Published online: 15 December 2023; doi:10.1038/s41551-023-01173-4When designing diagnostic assays intended for point-of-care use, more attention should be given to simplicity of operation.

Nature Biomedical Engineering, Published online: 15 December 2023; doi:10.1038/s41551-023-01173-4

When designing diagnostic assays intended for point-of-care use, more attention should be given to simplicity of operation.

A neural network that enables flexible nonlinear inference from neural population activity

Nature Biomedical Engineering, Published online: 12 December 2023; doi:10.1038/s41551-023-01111-4We show that nonlinear latent factors and structures in neural population activity can be modelled in a manner that allows for flexible dy…

Nature Biomedical Engineering, Published online: 12 December 2023; doi:10.1038/s41551-023-01111-4

We show that nonlinear latent factors and structures in neural population activity can be modelled in a manner that allows for flexible dynamical inference, causally, non-causally and in the presence of missing neural observations. Further, the developed neural network model improves the prediction of neural activity, behaviour and latent neural structures.

Tooling up against mechanobiological orthodoxy

Nature Biomedical Engineering, Published online: 15 November 2023; doi:10.1038/s41551-023-01159-2Increasingly physiological in vitro models and techniques for measuring forces at multiple scales are enabling unanticipated findings in t…

Nature Biomedical Engineering, Published online: 15 November 2023; doi:10.1038/s41551-023-01159-2

Increasingly physiological in vitro models and techniques for measuring forces at multiple scales are enabling unanticipated findings in tissue mechanopathology.

Intrinsic RNA-targeting activity limits the applicability of CRISPR–Cas13

Nature Biomedical Engineering, Published online: 31 October 2023; doi:10.1038/s41551-023-01124-zWe revealed that the RNA-targeting activity of the Cas13 family of nucleases allows them to directly target endogenous RNA in mammalian cel…

Nature Biomedical Engineering, Published online: 31 October 2023; doi:10.1038/s41551-023-01124-z

We revealed that the RNA-targeting activity of the Cas13 family of nucleases allows them to directly target endogenous RNA in mammalian cells. Such activity limits the usage of lentiviral Cas13 systems, and suggests a need for caution when applying Cas13-based systems.

Ever easier health monitoring

Nature Biomedical Engineering, Published online: 17 October 2023; doi:10.1038/s41551-023-01126-xThe management of health and of disease conditions will eventually be supported by ever more integrated and less conspicuous wireless bioel…

Nature Biomedical Engineering, Published online: 17 October 2023; doi:10.1038/s41551-023-01126-x

The management of health and of disease conditions will eventually be supported by ever more integrated and less conspicuous wireless bioelectronic devices designed to continuously monitor multiple biomarkers.

Squeezing more out from clinical imaging

Nature Biomedical Engineering, Published online: 17 August 2023; doi:10.1038/s41551-023-01087-1Leveraging or improving established technology for clinical imaging to extract additional physiological information can enhance the quality …

Nature Biomedical Engineering, Published online: 17 August 2023; doi:10.1038/s41551-023-01087-1

Leveraging or improving established technology for clinical imaging to extract additional physiological information can enhance the quality of the subsequent assessments and widen the technology’s uses.

Stem-cell-based functional genomics for the large-scale analysis of genetic variants

Nature Biomedical Engineering, Published online: 24 July 2023; doi:10.1038/s41551-023-01066-6We functionally assessed clinically observed mutations of the BRCA2 gene and analysed structure–function relationships of variants of the gene…

Nature Biomedical Engineering, Published online: 24 July 2023; doi:10.1038/s41551-023-01066-6

We functionally assessed clinically observed mutations of the BRCA2 gene and analysed structure–function relationships of variants of the gene by using high-throughput CRISPR-mediated mutagenesis and pooled screening in locally haploid human pluripotent stem cells and in fibroblasts differentiated from them.

A high-throughput workflow for comprehensive glycopeptide mapping

Nature Biomedical Engineering, Published online: 20 July 2023; doi:10.1038/s41551-023-01068-4We developed OxoScan-MS, a mass spectrometric acquisition technology for high-throughput quantification of glycopeptides. When applied to plas…

Nature Biomedical Engineering, Published online: 20 July 2023; doi:10.1038/s41551-023-01068-4

We developed OxoScan-MS, a mass spectrometric acquisition technology for high-throughput quantification of glycopeptides. When applied to plasma of patients with COVID-19, OxoScan-MS revealed differential glycosylation in disease-relevant proteins. This approach offers potential for large-scale applications, moving beyond traditional protein abundance measurements to explore glycosylated protein biomarkers.