Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells

Nature Biomedical Engineering, Published online: 19 April 2024; doi:10.1038/s41551-024-01194-7The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate i…

Nature Biomedical Engineering, Published online: 19 April 2024; doi:10.1038/s41551-024-01194-7

The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.